Talk to your doctor about the benefits and risks. Federman DG, Hussain F, Walters AB "Fatal rhabdomyolysis caused by lipid-lowering therapy. Kosoglou T, Meyer I, Veltri EP et al. Pharmacodynamic interaction between the new selective cholesterol absorption inhibitor ezetimibe and simvastatin. Br J Clin Pharmacol. If you smoke, it's time to quit. Set a date and talk to your doctor. If you've tried to quit before, it's not too late. Many people try several times before they kick the habit for good. Halkin A, Lossos IS, Mevorach D "HMG-CoA reductase inhibitor-induced impotence. cheap azathioprine 50 mg
The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs. Do not increase your dose or take this medication more often than prescribed. Your condition will not improve any faster, and the risk of serious side effects may be increased. Anthony DeMaria, MD, editor-in-chief of the Journal of the American College of Cardiology, says in a statement.
Rarely, statins may cause or worsen diabetes. Talk to your doctor about the benefits and risks. He may need to try different combinations of drugs and treatments until he finds one that works best for you. If you become or think you may be pregnant, tell your doctor right away. The concomitant administration of food high-fat vs. nonfat meals has no effect on the extent of absorption of ezetimibe. However, coadministration with a high-fat meal increases the C max of ezetimibe by 38%. The absolute bioavailability cannot be determined, since ezetimibe is insoluble in aqueous media suitable for injection. Ezetimibe and its active metabolite are highly bound to human plasma proteins 90%.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. If diet and drugs don't lower my cholesterol, are there other treatments that can help? Side Effects List Ezetimibe-Simvastatin Tablet side effects by likelihood and severity. Buildup of cholesterol and fats along the walls of the blood vessels a process known as atherosclerosis decreases blood flow, which decreases the oxygen supply to the heart, brain, and other parts of the body. Lowering blood levels of cholesterol and fats may help reduce this buildup and may decrease your chances of developing heart conditions such as angina chest pain strokes, and heart attacks. Results of a clinical study that compared people who took ezetimibe and simvastatin with people who took simvastatin alone found that although the group of people taking ezetimibe and simvastatin had lower amounts of cholesterol in the blood, there was no difference between the two groups in the amount of cholesterol and fat buildup on the insides of the blood vessels in the neck. It is not currently understood why the additional lowering of cholesterol levels in the blood did not lead to a greater decrease in cholesterol and fat buildup along the walls of the blood vessels in people taking ezetimibe and simvastatin. Further studies are underway to compare treatment with ezetimibe and simvastatin to treatment with simvastatin alone to see if there is a difference in the risk of developing heart disease. Talk to your doctor if you have questions about the risks and benefits of treating increased amounts of cholesterol in your blood with ezetimibe and other medications.
Vytorin simvastatin marketed as Zocor and ezetimibe marketed as Zetia: FDA investigates a report from the SEAS trial. Rockville, MD; 2008 Aug 21. Available from FDA website. Use alone or in combination with a hydroxymethylglutaryl-coenzyme A HMG-CoA reductase inhibitor statin as an adjunct to dietary therapy to decrease elevated serum total cholesterol, LDL-cholesterol, and apolipoprotein B apo B concentrations in the treatment of primary heterozygous familial and nonfamilial hypercholesterolemia. Read the Patient Information Leaflet if available from your before you start taking this product and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Omar MA, Wilson JP "FDA adverse event reports on statin-associated rhabdomyolysis. Have you noticed any yellowish patches on your skin? Store ezetimibe at 77 degrees F 25 degrees C. Brief storage at temperatures between 59 and 86 degrees F 15 and 30 degrees C is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep ezetimibe out of the reach of children and away from pets. Puijenbroek EP, Du Buf-Vereijken PW, Spooren PF, van Doormaal JJ "Possible increased risk of rhabdomyolysis during concomitant use of simvastatin and gemfibrozil. Importance of women informing their clinician if they are or plan to become pregnant or plan to breast-feed. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately.
ELDERLY; they may be more sensitive to its effects, especially muscle problems. Tell your doctor right away if you experience symptoms of liver problems eg, dark urine; pale stools; severe or persistent nausea, loss of appetite, or stomach pain; unusual tiredness; yellowing of the skin or eyes. After you've been diagnosed, you'll work closely with a cholesterol specialist called a lipidologist. It is unknown if this medication passes into breast milk. However, similar drugs pass into breast milk. Breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding. Reductions in sitosterol and campesterol concentrations were consistent between patients receiving ezetimibe with or without bile acid sequestrants. Patients should be placed on a standard cholesterol-lowering diet before initiation of ezetimibe therapy and should remain on this diet during treatment with the drug. Severe allergic reactions rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness; burning, numbness, or tingling; change in the amount of urine produced; confusion; depression; difficult, frequent, or painful urination; fever, chills, or persistent sore throat; joint pain; memory problems; muscle tenderness, pain, or weakness with or without fever and fatigue; persistent pain, soreness, redness, or swelling of a tendon or joint; red, swollen, blistered, or peeling skin; severe stomach or back pain with or without nausea or vomiting; symptoms of liver problems eg, dark urine, loss of appetite, pale stools, severe stomach pain, yellowing of the skin or eyes. Check your other meds. Check food labels to see how much fat is in the food you eat. Effects on cardiovascular morbidity and mortality not established. Effect of reducing plasma concentrations of sitosterol and campesterol on cardiovascular morbidity and mortality not established. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip themissed dose and resume your usual dosing schedule. benadryl
Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. Your doctor may try to reduce how much of your medicine you take. You might also be able to take a pill every other day instead of daily. Do not remove the tablet from the tablet pack until you are ready to take this drug. Take the tablet right away after opening the blister pack. Do not store the removed tablet for future use. If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Since homozygous familial hypercholesterolemia raises your cholesterol to extremely high levels, your doctor may start you on high doses of statin drugs. work by stopping your from making cholesterol. If you also take certain other drugs to lower your cholesterol bile acid-binding resins such as cholestyramine or colestipol take this product at least 2 hours before or at least 4 hours after taking these medications. These medications can react with this product, preventing its full absorption. Patients taking niacin also suffered fewer and other problems than those in the Zetia group, but that finding could have been due to chance, Taylor says. Two editorials accompanying the findings in The New England Journal of Medicine raised questions about the findings. latc.info linezolid
The findings are the second recent setback for Zetia. Do not share it with other people. Gaist D, Jeppesen U, Andersen M, Garcia Rodriguez LA, Hallas J, Sindrup SH "Statins and risk of polyneuropathy: a case-control study. It works by reducing the amount of cholesterol made by the liver. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Summary of the second report of the National Cholesterol Education Program NCEP Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults Adult Treatment Panel II. JAMA. Administer orally in the evening without regard to meals. Does your heartbeat ever seem rapid? ULN reported. 1 12 Elevations reported more frequently with ezetimibe-statin combination than with statin monotherapy. 1 Hepatitis reported; however, causal relationship not established. Take this by with or without food as directed by your doctor, usually once daily in the evening. Your ezetimibe might not work as well. Havranek JM, Wolfsen AR, Warnke GA, Phillips PS "Monotherapy with ezetimibe causing myopathy. Mild hepatic impairment: No dosage adjustment needed. Cholesterol is waxy stuff that's in your cells. 's job is to carry cholesterol around your body in your bloodstream. cost of allopurinol cough syrup
Schumacher YO, Zdebik A, Huonker M, Kreisel W "Sildenafil in HIV-related pulmonary hypertension. Read the Patient Information Leaflet if available from your pharmacist before you start taking this product and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Liptruzet. Liptruzet should not be used by women who are pregnant or may become pregnant as it may cause fetal harm. It is not known whether atorvastatin a component of Liptruzet is excreted into human milk. Another drug in this class passes into breast milk. Because statins have the potential for serious adverse reactions in nursing infants, breastfeeding is not recommended. Ezetimibe is an antihyperlipidemic agent. It works by reducing the amount of cholesterol that your body absorbs from your diet. Atorvastatin is an HMG-CoA reductase inhibitor or "statin. Ezetimibe inhibits the absorption of from the and decreases the amount of cholesterol normally available to cells, leading them to absorb more from circulation and thus lowering levels of circulating cholesterol. Roger Blumenthal, MD, and Erin Michos, MD, both of Johns Hopkins. The impotence resolved within 2 weeks after the HMG-CoA reductase inhibitor was discontinued. Does not appear to inhibit hepatic cholesterol synthesis or increase bile acid excretion. 1 Does not appear to inhibit absorption of triglycerides, fatty acids, bile acids, progesterone, or ethyl estradiol. 1 No clinically relevant effects on plasma concentrations of fat-soluble vitamins A, D, and E; 8 does not appear to impair adrenocortical steroid production. Abernethy DR, Greenblatt DJ, Morse DS, Shader RI "Interaction of propoxyphene with diazepam, alprazolam and lorazepam. Upon rechallenge 2 months later, the patient developed pain in the contralateral arm overlying the biceps tendon. Following discontinuation of ezetimibe-simvastatin, pain resolved 2 weeks later. Inhibition of matrix metalloproteinases has been suggested as the contributing factor in the development of tendon rupture. Importance of informing patients of other important precautionary information. 1 12 See Cautions. Follow your diet, medication, and exercise routines very closely.
Catapano AL, Reiner Z, De Backer G, et al. July 2011. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Nearly everyone with diabetes can benefit from getting more exercise. National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults: Adult Treatment Panel III Report. From AHA web site. New England Journal of Medicine. Preliminary results of this study in approximately 1900 patients revealed a higher incidence of cancer and fatal cancer in patients receiving fixed-combination preparation 11. Newman TB, Hulley SB "Carcinogenicity of lipid-lowering drugs. You go to a clinic or hospital where some of your blood is removed through a tube called a catheter. LDL cholesterol is taken out of your blood before it's returned to your body. The procedure takes several hours, and you'll need to do it regularly. Inc. Vytorin ezetimibe and simvastatin tablets prescribing information. Whitehouse Station, NJ; 2012 Jun. Schering-Plough. Vytorin ezetimibe and simvastatin tablets prescribing information. generic for fluconazole 20
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Check the label on the medicine for exact dosing instructions. Will my children inherit my condition? Moderate or severe hepatic impairment: Do not use. You may hear the term heterozygous familial hypercholesterolemia. This is a related disease. With it, you inherit the broken gene from only one of your parents. It's not as severe as the homozygous form. It's a serious condition. Without treatment, men with homozygous familial hypercholesterolemia can get in their 40s, and women can get it in their 50s. Simvastatin may harm an unborn baby. Therefore, it is important to prevent pregnancy while taking this medication. Itakura H, Vaughn D, Haller DG, O'Dwyer PJ "Rhabdomyolysis from cytochrome p-450 interaction of ketoconazole and simvastatin in prostate cancer. Inc. Zetia ezetimibe tablets prescribing information. Whitehouse Station, NJ; 2013 Aug. It may take up to 4 weeks before you get the full benefit of this drug. European Atherosclerosis Society, the Japan Atherosclerosis Society, the National Institute for Health and Clinical Excellence, and the International Atherosclerosis Society recommend ezetimibe as one of several second line treatment options for people who are intolerant of statins or who are unable to reach serum LDL goals using statins alone. Use in combination with fenofibrate as an adjunct to dietary therapy to decrease elevated serum total cholesterol, LDL-cholesterol, apo B, and non-HDL-cholesterol concentrations in the treatment of mixed dyslipidemia. 1 Effects on cardiovascular morbidity and mortality not established. 1 Use with a fibric acid derivative other than fenofibrate not studied and currently not recommended. 1 See Specific Drugs under Interactions. Has been shown to reduce concentrations of noncholesterol sterols, 8 including sitosterol and campesterol. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. It is not known if this medicine is found in breast milk. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Cannon, Christopher P. June 18, 2015. ditropan
Severe allergic reactions rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness; chest pain; dark urine; depression; fever, chills, or persistent sore throat; numbness or tingling of the skin; severe or persistent joint pain; severe stomach or back pain with nausea and vomiting; unexplained muscle pain, tenderness, or weakness; yellowing of the eyes or skin. Ezetimibe is primarily metabolized in the liver and the small intestine via glucuronide conjugation with subsequent renal and biliary excretion. Both the parent compound and its active metabolite are eliminated from plasma with a half-life around 22 hours, allowing for once-daily dosing. Ezetimibe lacks significant inhibitor or inducer effects on isoenzymes, which explains its limited number of drug interactions. Orsi A, Sherman O, Woldeselassie "Simvastatin-associated memory loss. At a news conference at the AHA meeting Sunday night, Taylor reported that the "winner" was Niaspan. Store at room temperature between 68-77 degrees F 20-25 degrees C away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets. Teramoto T, Sasaki J, Ishibashi S, et al. 2013. "Executive summary of the Japan Atherosclerosis Society JAS guidelines for the diagnosis and prevention of atherosclerotic cardiovascular diseases in Japan -2012 version". J. Atheroscler. Thromb. Schering-Plough Pharmaceuticals. Vytorin ezetimibe and simvastatin tablets prescribing information. North Wales, PA; 2011 Jun. Dujovne CA, Ettinger MP, McNeer JF et al for the Ezetimibe Study Group. Efficacy and safety of a potent new selective cholesterol absorption inhibitor, ezetimibe, in patients with primary hypercholesterolemia. Am J Cardiol. However, they all had suboptimal HDL levels. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company. Gagne C, Gaudet D, and Bruckert E for the Ezetimibe Study Group. Efficacy and safety of ezetimibe coadministered with atorvastatin or simvastatin in patients with homozygous familial hypercholesterolemia. Circulation. Importance of adherence to prescribed directions for use, particularly when used concomitantly with other antilipemic agents. This information is generalized and not intended as specific medical advice. You'll need to manage your condition throughout your life. Make sure you keep up with the drugs your doctor prescribes, and keep eating a healthy diet. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Ezetimibe may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. ranolazine
Vytorin ezetimibe marketed as Zetia and simvastatin marketed as Zocor. Rockville, MD; 2009 Jan 8. Available from FDA website. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using ezetimibe while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use ezetimibe, check with your doctor. Discuss any possible risks to your baby. Yellowish fat deposits called xanthelasmas can develop in your eyelids. Retrieved July 28, 2015. Simons LA "Simvastatin in severe primary hypercholesterolemia: efficacy, safety, and tolerability in 595 patients over 18 weeks. The Principal Investigators. Simvastatin has been associated with rare cases of severe myopathy and rhabdomyolysis. This is accompanied by elevations in creatine kinase, myoglobinuria, and proteinuria, as well as renal failure. Experience with HMG-CoA reductase inhibitors indicates that concomitant use with gemfibrozil, niacin, cyclosporine, or erythromycin may increase the incidence and the severity of musculoskeletal side effects. Some cholesterol medications should not be taken at the same time. Do not take ezetimibe with Prevalite, Questran Colestid or Welchol. Wait at least 4 hours after taking any of these medicines before you take ezetimibe. You may also take ezetimibe 2 hours before taking any of these other medicines. Vasc Health Risk Manag. Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details. Are there drugs that can help lower my cholesterol? Fixed combination of ezetimibe and simvastatin Vytorin : Category X due to simvastatin component.
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Ezetimibe may cause side effects. Report any unexplained muscle pain, tenderness, or weakness to your doctor right away, especially if you also have a fever or general body discomfort. What Is Homozygous Familial Hypercholesterolemia? Have you ever noticed that you're short of breath? cefdinir order now otc
The usual maximum dose for the simvastatin in this medication is 40 milligrams a day. If you have been instructed by your doctor to take more than 40 milligrams of simvastatin, continue on that same dose. However, promptly talk with him or her about the risks and benefits of your higher dose. You may have a blood test to look for the abnormal gene that causes this condition. Your doctor might also want to test some of your close relatives to see if they have the disease. Effects in patients currently undergoing LDL apheresis compared with those in patients not undergoing the procedure not established. price carbimazole last
Tell your doctor how your medicine makes you feel. Often, there are ways you can handle these side effects and still get the help you need for your cholesterol. Feldmann R, Mainetti C, Saurat JH "Skin lesions due to treatment with simvastatin Zocor. Department of Health and Human Services. Administer orally without regard to meals. Read the Patient Information Leaflet if available from your pharmacist before you start taking ezetimibe and each time you get a refill. If you have any questions, ask your doctor or pharmacist. vantin
Side Effects List Ezetimibe side effects by likelihood and severity. Blumenthal adds that several large of niacin and Zetia that are in progress should offer more guidance. Take ezetimibe by mouth with or without food. Nov. 16, 2009 Orlando, Fla. Ezetimibe is to be used only by the patient for whom it is prescribed. Do not share it with other people.